Voulgaroglou, Asimenia (2023) Insomnia: A risk factor for Alzheimer's disease? Bachelor's Thesis, Biology.
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Abstract
Alzheimer's disease imposes harmful effects on nearly half of the population,with sleep disturbances such as insomnia being a common repercussion. Recently, attention has shifted towards the potential of sleep disturbances serving as a predisposing factor for the onset of Alzheimer's disease. Consequently, this thesis will concentrate on insomnia as a potential risk factor for Alzheimer's disease, rather than simply a symptom. Findings indicate a link between the twoconditions, characterized by a decrease in slow-wave sleep duration and amplitude in insomnia patients, leading to elevated levels of Amyloid-beta. The thesis also explores disturbed glymphatic clearance as a potential mechanism underlying this increase. In conclusion, research suggests that Slow Wave Sleep (SWS) could potentially serve as a biomarker for early detection of Amyloid-beta accumulation. This insight could pave the way for alternative, non-invasive treatments targeting SWS enhancement
| Item Type: | Thesis (Bachelor's Thesis) |
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| Supervisor name: | Havekes, R. |
| Degree programme: | Biology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 07 Jun 2023 13:57 |
| Last Modified: | 07 Jun 2023 13:57 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/29943 |
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