Wennink, Megan (2023) The influence of SSRIs on the myelination of the auditory brain regions. Bachelor's Research Project (period 2b), Life Science and Technology.
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Abstract
18% of women experience depression during pregnancy. Nowadays, this is often treated with SSRIs. Both depression and SSRIs have a negative influence on the neurodevelopment of the unborn child and can cause mental and physical illness. Serotonin receptors are prevalent in the auditory brain regions, which makes it important to investigate whether exposure to SSRI during gestation influences these regions. Because serotonin also plays a role in the myelination of the brain, it would be interesting to further investigate the influence of SSRIs on the myelination in the inferior colliculus and the auditory cortex. Here, the influence will be tested on male rats, who were treated with fluoxetine or methylcellulose, and were sacrificed at PND 21 or PND 35. The brains were double stained for myelin associated glycoprotein (MAG) and myelin basic protein (MBP) with immunofluorescent histochemistry. It was found that the expression of MAG was reduced after PND 21 in both the inferior colliculus as in the auditory cortex, but the decrease between the control group and the fluoxetine group was only visible in the inferior colliculus at PND 35. This implies that the expression of MAG decreases as the myelination process decreases, and the process might go a bit faster since MAG is lower in fluoxetine PND 35 compared to control PND 35 in the inferior colliculus.
| Item Type: | Thesis (Bachelor's Research Project (period 2b)) |
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| Supervisor name: | Olivier, J.D.A. |
| Degree programme: | Life Science and Technology |
| Thesis type: | Bachelor's Research Project (period 2b) |
| Language: | English |
| Date Deposited: | 07 Jun 2023 14:39 |
| Last Modified: | 07 Jun 2023 14:39 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/29982 |
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