Assessing HandScan’s Predictive Value in RA Progression

Thomas, Ann (2023) Assessing HandScan’s Predictive Value in RA Progression. Master's Internship Report, Biomedical Engineering.

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Abstract

This internship aimed to evaluate the clinical value of the HandScan device in predicting progressive bone damage in rheumatoid arthritis (RA) patients compared to the golden standard for long-term outcomes in RA, i.e. the Sharp van der Heijde score. The study utilized the HandScan registry in Leeuwarden, which monitored daily clinical parameters and blinded HandScan measurements in over 500 RA patients during a two-year follow-up. Baseline data had been previously published, and additional data were being analyzed. The research question of whether the HandScan could provide a better prediction of progressive bone damage than DAS28 was addressed by applying the Sharp van der Heijde (SvdH) score on X-rays. A total of 728 photographs of hands and feet from 91 patients were scored at baseline and after a two-year from the registry. The patients were grouped based on the degree of joint damage progression, and their characteristics were compared. The Spearman correlation analysis revealed a positive monotonic relation between SvdH and TOS scores, as well as between DAS28 and TOS scores. These findings suggest that the HandScan (TOS) score may be associated with joint damage progression and disease activity. Subgroup analysis for disease progression showed a high and positive correlation between SvdH and TOS mean scores, while the DAS28 mean scores did not demonstrate the same results. The regression analysis indicated that the mean TOS score at baseline and mean TOS of patients p

Item Type:	Thesis (Master's Internship Report)
Supervisor name:	Renken, R.J.
Degree programme:	Biomedical Engineering
Thesis type:	Master's Internship Report
Language:	English
Date Deposited:	28 Jun 2023 07:56
Last Modified:	28 Jun 2023 07:56
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/30101

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