Culea, Mihaela (2023) Gender Differences Between Anatomical Characteristics and Mechanical Properties of Porcine Urethra. Bachelor's Thesis, Biomedical Engineering.
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Abstract
Urinary catheters, including the widely used Foley catheter, are essential for managing urine retention. However, they can lead to complications such as infections, primarily due to their design employing an inflated balloon. A promising solution consists of removing the balloon and engineering a coating that retains the catheter in place. This study investigates the urethra's anatomical characteristics and mechanical properties, intending to lay the groundwork for advanced catheter coatings. Extensive literature review and ex-vivo experiments using porcine urethra samples were conducted. Replicas of the urethral lumen were created using polydimethylsiloxane (PDMS) and analyzed through 3D scanning. This confirmed the irregular and non-circular nature of the luminal surface in the porcine urethra, as well as the anatomical structural distinctions between the two genders. Mechanical properties of different urethral sections were assessed using a Low Load Compression Testing (LLCT) machine, with a specific emphasis on stiffness and percentage of relaxation values. The mean stiffness remained consistent across all regions and between genders. Conversely, notable differences were observed in the relaxation percentage between the aforementioned independent variables. The primary aim of this research is to to provide a comprehensive understanding of the male and female porcine urethra, that will contribute to the development of safer and more efficient urinary catheter coatings.
| Item Type: | Thesis (Bachelor's Thesis) |
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| Supervisor name: | Sharma, P.K. |
| Degree programme: | Biomedical Engineering |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 05 Jul 2023 07:29 |
| Last Modified: | 05 Jul 2023 07:29 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/30215 |
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