Assessment of an experimental ex vivo perfusion setup of ovine hearts based on pressure-volume analysis by a MATLAB model

Wijntjes, Bart (2023) Assessment of an experimental ex vivo perfusion setup of ovine hearts based on pressure-volume analysis by a MATLAB model. Master's Internship Report, Biomedical Engineering.

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Abstract

Transplanting a health heart into a patient is common treatment for chronic heart failure. However, donor hearts are not commonly available. Often DBD hearts are used and DCD hearts are put aside. DCD hearts could lead to a large increase of the donor pool, if properly assessed. Such assessment of the heart can be done based on PV-measurement analysis. Especially contractility of the heart is a useful parameter in assessing the cardiac function before transplanting. The aim of this project was to develop a predictive model of contractility parameters of the heart based on PV-measurements of sheep hearts in a custom ex-vivo experimental setup. The model was developed in MATLAB and the main focus of the model was on calculating and visually representing the parameters end-systolic pressure volume ratio (ESPVR), end-systolic elastance (Ees), arterial elastance (Ea) and the ratio Ea/Ees. These parameters were compared to reference values found in literature. Parameters ESPVR and Ees were considered within acceptable range of the reference values. Parameter Ea was calculated in two ways, the first by taking the mean of each cycle (Ea) and the second by fitting a line between the EDV points and pressure maxima (Ea fit). Ea fit was considered more accurate than Ea with respect to the reference values. The ratio of Ea/Ees for both types of Ea varied a lot, leading to the conclusion that further validation of the calculation of Ea is required before the model can be deemed accurate.

Item Type:	Thesis (Master's Internship Report)
Supervisor name:	Erasmus, M.E. and Fluit, M.
Degree programme:	Biomedical Engineering
Thesis type:	Master's Internship Report
Language:	English
Date Deposited:	05 Jul 2023 13:00
Last Modified:	05 Jul 2023 13:00
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/30347

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