Promising renin-angiotensin system treatments in lung diseases

Kreeft, Jorn (2023) Promising renin-angiotensin system treatments in lung diseases. Master's Thesis / Essay, Biomolecular Sciences.

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Abstract

The renin-angiotensin system (RAS) is known for maintaining homeostasis of blood levels and body fluids in humans; recent studies extended that view on the RAS. Further research shows that the RAS is also related to multiple other occurrences in the human body, including organ injury and pathologies of several diseases (Vargas et al., 2022). Thus, the classical RAS ACE/Ang II/AT1R regulatory axis and both the ACE2/Ang-(1-7)/MasR and ACE/Ang II/AT2R counter-regulatory axes are very important to the human body, in general. RAS treatment can prevent and/or treat lung diseases and lung injuries (Tseng et al., 2020). In this thesis, promising RAS treatment for pulmonary fibrosis and COVID-19, two lung diseases, are reviewed. In the introduction, the key hormone regulation system, RAS, is explained in detail and especially the components of the RAS which are interesting for treatment. Furthermore, two lung diseases/injuries of interest are introduced which are pulmonary fibrosis and COVID-19. Treatment for pulmonary fibrosis is reviewed in more detail whereas treatment for COVID-19 is shortly described. The relation between the RAS in lung tissue and the particular disease is explained. Thus, the role of the RAS in the pathogenesis process of lung fibrosis/COVID-19 is explained and how the RAS is modified after lung fibrosis/COVID-19 pathogenesis. By ‘modified’ is meant: the different levels of the components of the RAS between healthy circumstances and when infected with the with the disease. The pros and cons of potential distinct RAS treatments are considered for each particular lung disease.

Item Type:	Thesis (Master's Thesis / Essay)
Supervisor name:	Moll, G.N. and Broos, J.
Degree programme:	Biomolecular Sciences
Thesis type:	Master's Thesis / Essay
Language:	English
Date Deposited:	13 Jul 2023 10:47
Last Modified:	13 Jul 2023 10:47
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/30599

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