Oosterhout, Emily (2023) Molecular Nutrition; a metabolic approach for nutritional assessment in inflammatory bowel disease. Master's Research Project 2, Biomedical Sciences.
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Abstract
Background: Around 7 million people worldwide are diagnosed with inflammatory bowel disease (IBD), which is the overarching term used to describe Crohn’s disease (CD) and ulcerative colitis (UC). All patients diagnosed with IBD experience periods of active illness followed by periods of remission; suggesting that environmental factors play an important role in the presence of IBD symptoms and symptom severity. Previous studies have identified dietary factors including red meat and emulsifiers to be associated with the onset of IBD and disease severity. While dietary patterns are well studied in this context, limited data is present on the specific mechanisms driving this association. Methods: To gain more precision in studying dietary factors related to disease, we have implemented a data algorithm calculating dietary compounds from food measured by the Food Frequency Questionnaire (FFQ). This calculation was performed using the web-based food compound database FooDB. Blood and fecal samples from the same participants were used to measure metabolites present in plasma and feces, which were subsequently correlated to the derived dietary compounds. Results: Derived intake of carbohydrates and fiber correlates well with fecal and serum succinate, whereas tryptophan intake shows a stronger correlation with its metabolites in serum compared to feces. Secondly, dietary compounds; pentanoic acid (p < .05) and selenium (p < .05) are negatively associated with IBD diagnosis and intestinal inflammation. Amongst others, these anti-inflammatory compounds are found to be more prevalent in the diet of healthy individuals compared to IBD patients (p < .001). Conclusions: By taking a metabolic approach of studying the role of diet in IBD patients, we can gain a better understanding of the role of specific dietary compounds in active inflammation. The main results of this study form a basis for more targeted dietary approaches and patient-tailored advice to prevent intestinal inflammation through integration of newly discovered metabolomic and dietary profiles.
| Item Type: | Thesis (Master's Research Project 2) |
|---|---|
| Supervisor name: | Bolte, L.A. and Vich Vila, A. and Weersma, R.K. |
| Degree programme: | Biomedical Sciences |
| Thesis type: | Master's Research Project 2 |
| Language: | English |
| Date Deposited: | 31 Jul 2023 12:55 |
| Last Modified: | 16 Aug 2023 14:20 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/30737 |
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