Bosma, Janneke (2023) Weighing the options: animal models for multiple sclerosis. Master's Thesis / Essay, Biomedical Sciences.
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Abstract
Multiple sclerosis (MS) is a chronic demyelinating, autoimmune disease of the central nervous system (CNS). The usage of animal models is essential for MS research. However, animals don’t naturally develop MS as the disease is exclusive to humans. Therefore, many models for MS exist with varying strengths and weaknesses regarding different aspects of the disease. The aspects of the disease that need to be represented in good animal models are demyelination and remyelination of lesions, inflammation, and neurodegeneration. Toxin- based models like Cuprizone- and Lysolecithin-induced demyelination, as well as virus-induced models such as Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD), are looked into. Additionally, experimental autoimmune encephalomyelitis (EAE) models in rodents, including myelin oligodendrocyte glycoprotein (MOG)-induced EAE, T cell transfer EAE, EAE with cytokine-induced focal cortical pathology, and marmoset EAE are investigated. Additionally, the importance of considering gender in MS research is discussed, emphasizing the need for adequate representation of female animals following the relatively high prevalence of MS in females. Due to the absence of a universally perfect animal model for MS, it is crucial to carefully select a model that aligns with the specific aspects of the disease relevant to the research question at hand.
| Item Type: | Thesis (Master's Thesis / Essay) |
|---|---|
| Supervisor name: | Eisel, U.L.M. and Baron, W. |
| Degree programme: | Biomedical Sciences |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 20 Jul 2023 12:57 |
| Last Modified: | 20 Jul 2023 12:57 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/30818 |
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