Lifestyle interventions modulate cellular senescence markers in the context of Alzheimer’s Disease

Garcia Baucells, Pau (2023) Lifestyle interventions modulate cellular senescence markers in the context of Alzheimer’s Disease. Master's Research Project 2, Biomedical Sciences.

Preview	Text mBMS_2023_GarciaBaucellsP.pdf Download (9MB) | Preview
	Text toestemming.pdf Restricted to Registered users only Download (133kB)

Abstract

The irreversible block of the cell cycle, cellular senescence, has recently gained interest in the aging field. Senescence has been found to contribute to Alzheimer’s Disease (AD) pathology and the resulting loss of cognition that patients go through. Considering that lifestyle interventions such as exercise, diet or anti-inflammatory supplementation have been linked with improved symptomatology in AD patients, we assessed how senescence markers behaved under these regimens. Analysis of whole blood from patients suffering from AD demonstrated a sex-specific difference in the senescence marker p16. In the same line, 5XFAD male mice also displayed more p16 transcription and protein content. Despite a marked pathological and cognitive improvement following exercise, senescence markers remained unchanged in this AD model. High-fat diet, which is described to be pro-inflammatory, increased senescence in the 5XFAD background. Complementary, anti-inflammatory perinatal treatment was also able to decrease senescence in young mice, highlighting how inflammation and senescence are intertwined. In the present work, we propose an inflammation–based model, in which lifestyle interventions are able to decrease senescent cells by indirectly mediating senomorphic capabilities. Whether these observations will prove to be critical in the clinical practice is yet unknown, but understanding cellular senescence in the context of neuroinflammation will be critical for AD and age-related diseases.

Item Type:	Thesis (Master's Research Project 2)
Supervisor name:	Dolga, A.M.
Degree programme:	Biomedical Sciences
Thesis type:	Master's Research Project 2
Language:	English
Date Deposited:	26 Jul 2023 06:19
Last Modified:	26 Jul 2023 06:19
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/30902

Actions (login required)

View Item