Kuperus, Jenny (2023) Influence of perinatal fluoxetine exposure on myelination during brain development. Master's Research Project 1, Biomedical Sciences.
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Abstract
A high number of infants are exposed to antidepressant medication prior to birth and/or during lactation due to mental illness of the mother. The most used antidepressants are selective serotonin reuptake inhibitors (SSRIs), which can cross both the placenta and blood-brain barrier and are found in breast milk. Altered serotonin levels due to SSRI use during the developmental period can lead to disrupted brain development. Both human and animal studies have found that exposure to the SSRI fluoxetine during pregnancy and lactation impacts both behaviour and physiology in the offspring. Further, perinatal fluoxetine exposure can enhance myelin-related gene expression in the prefrontal cortex, and it can inhibit this gene expression in the basolateral amygdala at postnatal day 21 in male, but not female rats. This may suggest an acceleration of myelination and development. To determine whether myelination is accelerated due to perinatal fluoxetine exposure, gene expression of four myelin-related genes - myelin-associated glycoprotein (Mag), myelin basic protein (Mbp), Claudin-11 (Cldn11), and 2’,3’-cyclic-nucleotide 3’phosphodiesterase (Cnp) - in the basolateral amygdala and prefrontal cortex at postnatal day 1, 7, and 14 were measured. Female Wistar rats received a daily dose of either fluoxetine (FLX; 10 mg/kg) or vehicle (autoclaved water) orally from gestational day 1 until weaning. Male and female offspring brains were collected at postnatal day 1, 7, and 14.
| Item Type: | Thesis (Master's Research Project 1) |
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| Supervisor name: | Olivier, J.D.A. |
| Degree programme: | Biomedical Sciences |
| Thesis type: | Master's Research Project 1 |
| Language: | English |
| Date Deposited: | 27 Jul 2023 09:19 |
| Last Modified: | 27 Jul 2023 09:19 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/30945 |
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