Yurova, Mariia (2023) The Lessons of Hunger: Insights from Animal Models and Aberrant Reward in Anorexia Nervosa. Master's Thesis / Essay, Behavioural and Cognitive Neurosciences.
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Abstract
Anorexia nervosa (AN) is a debilitating mental condition with the highest mortality rate among all psychiatric disorders. AN is a multi-component disease, involving influences of environmental, genetic and psychological factors. AN individuals exhibit immense preoccupation with food and the body, causing complete food withdrawal and resulting severe emaciation. Women are much more susceptible to developing the condition than males. AN often occurs concurrently with other mental illnesses, such as major depressive disorder, suicidal ideation, and obsessive-compulsive disorder. The research on AN is extremely complex, as the disease encompasses psychological, behavioral, and neurobiological domains. Nonetheless, there have been significant advancements in studying neurobiological circuits in AN to drawing insights in disease understanding. Specifically, the abnormal reward circuitry function together with dopaminergic transmission proved to play a considerable part in AN pathology. While animal research cannot mimic all features of the human condition, it can provide mechanistic insights into how the disease develops and progresses. Some animal models are based on environmental factors while others include genetic alterations; all, however, give rise to some core aspects of AN and are indispensable for studying the disease, helping elucidate its pathological course.
| Item Type: | Thesis (Master's Thesis / Essay) |
|---|---|
| Supervisor name: | Scheurink, A.J.W. |
| Degree programme: | Behavioural and Cognitive Neurosciences |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 28 Aug 2023 10:16 |
| Last Modified: | 28 Aug 2023 10:16 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/31290 |
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