Zantinge, Danique (2023) Sleep and cognition in rodents: Experience-dependent activity and spindle characteristics in the cortex. Master's Research Project 2, Biomedical Sciences.
|
Text
mBMS_2023_ZantingeDC.pdf Download (1MB) | Preview |
|
![[img]](https://fse.studenttheses.ub.rug.nl/style/images/fileicons/text.png) |
Text
toestemming.pdf Restricted to Registered users only Download (130kB) |
Abstract
NREM spindles during sleep show a strong correlation between variations in spindle events and markers of cognitive functioning. As well as sleep, spindles also show a circadian rythmicity, although this has not been thoroughly studied in rodents. Furthermore, this suggests that spindle characteristics can be influenced by cognitive stimulation, for example through enriched environment. The relationship between sleep and cognitive processing can be studied using a sensory perceptual novel object recognition task, which is used to assess cognitive processing in the somatosensory cortex. In this study, we focused on determining the influence of sleep deprivation after learning on molecular markers of experience-dependent activity in the somatosensory cortex in mice, as well as to characterise changes in spindle events across the 24-hour circadian time and in response to cognitive stimulation using enriched environment exposure in rats. We show that sleep may be important for object recognition in our sensory perceptual learning variant of the NORT and that complex sensorimotor learning does not influence sleep markers of cognition, spindles specifically.
| Item Type: | Thesis (Master's Research Project 2) |
|---|---|
| Supervisor name: | Havekes, R. |
| Degree programme: | Biomedical Sciences |
| Thesis type: | Master's Research Project 2 |
| Language: | English |
| Date Deposited: | 30 Aug 2023 14:21 |
| Last Modified: | 30 Aug 2023 14:21 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/31340 |
Actions (login required)
 |
View Item |