The Gut Microbiome: how it may affect the course of Parkinson’s disease

Lanting, Nephthys (2023) The Gut Microbiome: how it may affect the course of Parkinson’s disease. Master's Thesis / Essay, Nanoscience.

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Abstract

Parkinson’s disease (PD) is a growing problem as the mean age of the world’s population increases and it has been the second most prevailing neurodegenerative disease in the world. Lately, the influence of the gut microbiome (GM) on PD has been studied. Because of the therapeutic potential through a combination of diet and faecal microbiota transplantation, the gut-microbiome has received more appreciation. In this paper the role of the GM is discussed firstly in gut diseases, but later focusses on neurodegenerative diseases, in particular PD. It has been more evident that the composition of the gut microbiota is altered in patients suffering from irritable bowel syndrome or inflammatory bowel disease, but recently studies have shown that the GM is also disturbed in patients suffering from Alzheimer’s disease (AD) and PD. The dysbiosis in the gut seem to affect the α-synuclein (α-syn) pathology in PD and may result in short-chain fatty acids (SCFAs) disruption. Although, it is not yet clear if SCFAs have a positive or negative influence on the course of PD. The impact of heavy metals, in principal manganese, on PD is shortly discussed. The interplay between the GM and the main treatment of PD, levodopa, is reviewed.

Item Type:	Thesis (Master's Thesis / Essay)
Supervisor name:	Eisel, U.L.M. and Falcao Salles, J.
Degree programme:	Nanoscience
Thesis type:	Master's Thesis / Essay
Language:	English
Date Deposited:	31 Aug 2023 09:44
Last Modified:	31 Aug 2023 09:44
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/31357

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