Takla, Maria (2024) Emerging evidence on a potential link between DNA methylation and Attention Deficit Hyperactivity Disorder (ADHD). Master's Thesis / Essay, Biology.
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Abstract
This essay attempts to explore epigenetic mechanisms, particularly DNA methylation, in the context of Attention-Deficit/Hyperactivity Disorder (ADHD). ADHD is a neurodevelopmental condition affecting millions globally. Individuals with ADHD face significant life challenges, from academic and occupational struggles to strained interpersonal relationships. Its prevalence is estimated at 8% globally, highlighting its societal impact. Even though a great number of studies have focused on it, the underlying mechanisms are yet poorly understood. In this context, exploring epigenetic factors can provide a unique lens to comprehend the dynamic interplay between genetic predispositions and environmental influences that shape ADHD. In a thorough examination of candidate-gene studies and Epigenome-Wide Association Studies (EWAS), the essay highlights the most frequent findings, centering on genes like VIPR2, DDR4, and DAT1. Despite promising discoveries, the prevailing heterogeneity of the results requires further discussion, exploration of possible reasons and novel perspectives. Acknowledging the challenges, a combination of longitudinal studies and more targeted study designs, might help capturing the dynamic nature of epigenetic modifications in ADHD, paving the way for prevention, stratification, and targeted interventions.
| Item Type: | Thesis (Master's Thesis / Essay) |
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| Supervisor name: | Kas, M.J.H. and Olivier, J.D.A. |
| Degree programme: | Biology |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 29 Jan 2024 10:13 |
| Last Modified: | 29 Jan 2024 10:13 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/31849 |
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