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Deep Brain Stimulation In Anorexia Nervosa

Westerhuis, Harmen (2024) Deep Brain Stimulation In Anorexia Nervosa. Master's Thesis / Essay, Biomedical Sciences.


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Ever since Anorexia Nervosa (AN) has been described in 1873, there have been no major improvements in the aetiology and treatment of the disorder. Anorexia Nervosa (AN) is a neuropsychiatric disorder in which the patients compulsively starve themselves, experiences anxiety, have a BMI of <17 kg/m2, and has the highest mortality of any neuropsychiatric disorder. About 4% of women and 0.3% of men develop AN during their lifetime and 5% of AN patients do not survive the first 4 years after diagnosis. Deep Brain Stimulation (DBS) is used as a final resort to treat treatment-resistant neuropsychiatric disorders. In order to improve the DBS treatment of AN, the aetiology of AN should be clarified. The aetiology of AN is difficult to pinpoint as different aspects of the disorder overlap with aspects of addiction, Obsessive-Compulsive Disorder (OCD), and depression and anxiety. Patients with AN often show addictive behaviour towards exercise and weight loss. Obsessive-compulsive symptoms are also often seen in AN. Finally, patients with AN experience several depressive-like symptoms and experience social anxiety. In OCD, addiction, and depression and anxiety, the Nucleus Accumbens (NAc) is often targeted by DBS. The ventral Anterior Limb of the Internal Capsule (vALIC) is used as a DBS target in both OCD and depression and anxiety. The Bed Nucleus of the Stria Terminalis (BNST) is targeted by DBS only in OCD. Finally, the Subcallosal Cingulate Cortex (SCC) is targeted by

Item Type: Thesis (Master's Thesis / Essay)
Supervisor name: Scheurink, A.J.W.
Degree programme: Biomedical Sciences
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 29 Jan 2024 10:20
Last Modified: 29 Jan 2024 10:20

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