E19B-19k as novel target against human adenovirus infections

Ploeg, Noa van der (2024) E19B-19k as novel target against human adenovirus infections. Master's Thesis / Essay, Medical Pharmaceutical Sciences.

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Abstract

Human adenoviruses are a diverse group of pathogens that cause a wide range of illnesses. One key aspect in the virus is the E1B-19k protein, which plays a crucial role in viral replication and host immune evasion. The protein does this by inhibiting apoptosis via binding to the pro-apoptotic factors BAK, BAX and BIK from the Bcl-2 family. Additionally, the protein presents caspase activation by interacting with dead domains (DDs) in TNFR1, Fas and TRAIL. Fas-mediated apoptosis involves FADD and procaspase 8; E1B-19k blocks this apoptotic pathway and thereby enhancing survival of the virus and replication in the host cells. A correct understanding of these mechanisms is crucial in the development of targeted antiviral strategies. This essay focuses on the role of E1B-19k in replication of human adenoviruses and its potential as a target for antiviral strategies. Current antivirals for human adenoviruses are discussed, together with proposals of novel strategies using E1B-19k as a target.

Item Type:	Thesis (Master's Thesis / Essay)
Supervisor name:	Rafie, K. and Schmidt, M.
Degree programme:	Medical Pharmaceutical Sciences
Thesis type:	Master's Thesis / Essay
Language:	English
Date Deposited:	31 Jan 2024 15:48
Last Modified:	31 Jan 2024 15:48
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/31876

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