The role of CD36 in the development of high-fat diet-induced diabetic cardiomyopathy

Veenstra, Manon (2024) The role of CD36 in the development of high-fat diet-induced diabetic cardiomyopathy. Bachelor's Thesis, Biology.

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Abstract

Consumption of high-fat diets contributes to the increased prevalence of individuals with obesity and type-2 diabetes. These individuals have an increased risk of developing diabetic cardiomyopathy, which can result in heart failure and mortality. This review discusses the current knowledge regarding the central role of cluster of differentiation 36 (CD36) in the development of diabetic cardiomyopathy. CD36, a transmembrane protein, regulates the uptake of fatty acids in cardiomyocytes and can cycle between the cell surface (sarcolemma) and acidified endosomes (intracellular storage compartments). An important regulator of CD36 cycling is v-ATPase, a proton pump that acidifies endosomes. High levels of fatty acids can disassemble v-ATPase, which causes CD36 to be relocated to the sarcolemma. This causes a feed- forward mechanism whereby more fatty acids are taken up, which drives several changes within the heart, such as lipid accumulation and lipotoxicity, insulin resistance and a shift in energy metabolism towards lipid metabolism, at the expense of glucose metabolism, resulting in contractile dysfunction. Eventually, through these changes, CD36 contributes to the development of diabetic cardiomyopathy. Therapies that (indirectly) target CD36 through v-ATPase seem to be promising treatments. Further research into these therapies, and the mechanisms of action of CD36, will help to understand the development of diabetic cardiomyopathy and the most effective ways to treat it.

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Koonen, D.P.Y.
Degree programme:	Biology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	12 Apr 2024 14:41
Last Modified:	12 Apr 2024 14:41
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/32285

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