Sietsma, Tiemen Mart (2024) How are the mechanisms that drive Idiopathic pulmonary fibrosis similar or different to other types of fibrosis. Bachelor's Thesis, Biology.
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Abstract
It has been hard to diagnose people with IPF since many of the symptoms of IPF are very similar to those of other lung diseases(1). This could be because fibrosis is seen in other diseases more as a resulting phenomenon than the cause of the disease itself. The most prevalent types of fibrosis are of the lungs and skin but it also occurs in many other places such as the heart and the liver. Because fibrosis is seen in many other tissues it might be interesting to see if this pathology is similar. Among the other types of fibrosis that have similar pathologies with IPF they also tend to differ in the tissues or cells that are affected as well as the type of cells and immunological response to those cells. The mechanisms that drive IPF such as fibroblasts differentiation into myofibroblasts are generally seen in these other types as well(6). The activation of fibroblasts where signaling molecules and intricate molecular pathways are coming into play is crucial for fibroblast differentiation. The signaling molecules themself might differ both in form and function but some of them might also be the same for all types of fibrosis which could help in understanding the interplay better between said forms of fibrosis. Herein, I review the most important pathways and mechanisms that drive both IPF as well as skin, liver and cardiac fibrosis.
| Item Type: | Thesis (Bachelor's Thesis) |
|---|---|
| Supervisor name: | Burgess, J.K. |
| Degree programme: | Biology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 29 Apr 2024 10:36 |
| Last Modified: | 29 Apr 2024 10:36 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/32339 |
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