The effect of sex, age, and menopause on antidepressant and mood stabiliser pharmacokinetics

Bosch, Eline (2024) The effect of sex, age, and menopause on antidepressant and mood stabiliser pharmacokinetics. Research Project, Pharmacy.

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Abstract

Men and women differ from each other physiologically leading to pharmacokinetic differences between sexes. These differences have not been thoroughly evaluated for antidepressants and mood stabilisers yet, resulting in uniform drug treatment for men and women thus far, which can lead to suboptimal treatment of diseases. Apart from sex, aging and menopausal status also influence drug pharmacokinetics. This study aims to investigate the effects of age, sex and menopause on antidepressant and mood stabiliser pharmacokinetics, with a focus on metabolic enzyme activity. C/D ratios, metabolite to parent compound ratios and serum levels of antidepressants and mood stabilisers were analysed over age, sex and estimated menopausal status by performing statistical analysis in R studio using linear mixed effect modelling. Our study provides new insights into antidepressant and mood stabiliser metabolism and clearance, and also sheds light on the differences in activity of specific metabolic enzymes (CYP1A2, CYP2D6, CYP2C19, CYP3A4, UGT) and renal clearance over age, sex, and menopausal status. This highlights the importance of taking these factors into account in treatment guidelines.

Item Type:	Thesis (Research Project)
Supervisor name:	Touw, D.J. and Sommer, I.E.C.
Degree programme:	Pharmacy
Thesis type:	Research Project
Language:	English
Date Deposited:	03 May 2024 11:17
Last Modified:	03 May 2024 11:17
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/32366

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