Aspects of pathogenesis, infection and lipid metabolism of Leishmania species

Bottema, Rjimke (2024) Aspects of pathogenesis, infection and lipid metabolism of Leishmania species. Master's Thesis / Essay, Biomolecular Sciences.

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Abstract

Leishmania can be found in and in the vicinity of the majority of the world’s (sub)tropical countries and is mostly transmitted via sandflies. There are around 20 different species of Leishmania that are known to infect humans. The parasite, which is transmitted via sandflies, is known to infect white blood cells. Cells that are able to sustain Leishmania infection are, amongst others, macrophages, inflammatory monocytes, neutrophils and dendritic cells. Other cell types have also been found to sustain Leishmania infection, which are endothelial and epithelial cells, fibroblasts, keratinocytes, chondrocytes and myoblasts. The parasite occurs in two different forms. Inside the mammalian cell, it resides as an amastigote. Within the sandfly and during the initial infection, the parasite is in its promastigote form. The parasite replicates as an amastigote inside the cell and after cell rupture it infects other cells in the vicinity. The pathogenesis differs between species and can be categorised into three major types: visceral leishmaniasis, mucocutaneous leishmaniasis and cutaneous leishmaniasis. In this essay, multiple aspects per species that are known to infect humans are described. In addition, I have discussed the pathogenesis of Leishmania together with currently available treatment options. Furthermore, the different mechanisms the promastigote form of Leishmania might use to infect the mammalian cell are discussed. Focussed sections discuss how the parasite enters the

Item Type:	Thesis (Master's Thesis / Essay)
Supervisor name:	Moll, G.N.
Degree programme:	Biomolecular Sciences
Thesis type:	Master's Thesis / Essay
Language:	English
Date Deposited:	06 Jun 2024 13:53
Last Modified:	06 Jun 2024 13:53
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/32626

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