Russchen, Dionne (2024) Escitalopram in combination with drug X inhibits sexual behavior after an aggressive encounter. Bachelor's Research Project (period 2b), Biology.
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Abstract
The most common male sexual disorder is premature ejaculation (PE). PE lacks an efficient on demand treatment. At the moment, topical anesthetic agents and SSRIs are the most used to treat PE, but they lack efficiency and bear several side-effects. It has been recently shown that the addition of the 5-HT1a-receptor antagonist drug X to a SSRI acutely inhibits sexual behavior in Wistar male rats. In order to confirm the potential of drug X in combination with a different SSRI to be a treatment for PE, we tested the combination of escitalopram with drug X in a dose dependent manner. Groningen wild-type rats were sexually trained for 6 weeks and underwent the resident-intruder test. Hereafter, the drug combinations were tested in a dose-dependent manner for aggressive and sexual behavior. The results showed that escitalopram together with either 20 or 10 mg/kg drug X inhibits sexual behavior after an aggressive encounter in comparison to the basal sexual behavior of the rats. Furthermore, the resident-intruder test seems to have an impact on sexual behavior, since the rats of all drug combinations showed less sexual behavior in comparison to the basal sexual behavior. This could perhaps be caused by the perceived stress of the aggressive encounter or sexual satiety. Although our results were impacted by the aggressive encounter, we can conclude that escitalopram together with drug X seems to inhibit sexual behavior.
| Item Type: | Thesis (Bachelor's Research Project (period 2b)) |
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| Supervisor name: | Drion, C.M. and Scheurink, A.J.W. and Olivier, J.D.A. |
| Degree programme: | Biology |
| Thesis type: | Bachelor's Research Project (period 2b) |
| Language: | English |
| Date Deposited: | 26 Jun 2024 12:14 |
| Last Modified: | 26 Jun 2024 12:14 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/32759 |
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