Feij, Paul (2024) The Role of Amyloid Precursor Protein in Accelerated Alzheimer's Disease in Down Syndrome: A Literature Review. Bachelor's Thesis, Biology.
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Abstract
Down syndrome (DS) is a relatively common cause of intellectual impairment which is caused by a triplication of the 21st chromosome, leading to various health complications and the typical DS phenotype, but also often an accelerated form of Alzheimer’s disease (AD). In this literature review we explore the intricate role of the amyloid precursor protein (APP) gene, which is located on the 21st chromosome and increased in expression, for the progression of AD in DS. This review shows how trisomy 21 increases production of everything in the APP processing pathways, significantly increasing risk for AD. There are more genes than APP which contribute to AD progression than APP, like DYRK1A or BACE2, but their complete roles and functions have to be studied more. To begin treating or diagnosing AD in DS with novel biomarkers discussed in this paper, which could present us with better ways to diagnose AD or treat AD from angles we haven’t been able to see yet, their complete mechanisms have to be known in future research.
| Item Type: | Thesis (Bachelor's Thesis) |
|---|---|
| Supervisor name: | Eisel, U.L.M. and Jorna, L.M. |
| Degree programme: | Biology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 03 Jul 2024 13:01 |
| Last Modified: | 05 Jul 2024 09:01 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/33022 |
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