Gormezano Kasuto, Iris (2024) Cyanobacteria as Cell Factories for the Sustainable Production of Indigo from CO2. Bachelor's Thesis, Life Science and Technology.
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Abstract
Concrete evidence of the effects of climate change in recent years has encouraged a transition from the petrochemical paradigm to a circular economy model by developing more sustainable industrial processes. This review discusses the viability of using cyanobacteria as cell factories to replace the traditional indigo dye synthesis that is environmentally harmful. These biofactories could utilize carbon dioxide, mitigating the need for an organic source of carbon, that is in competition with other processes. Recent advancements in greener approaches are discussed, and a promising bifunctional enzyme that converts L-tryptophan to indigo is highlighted since it was the most productive. The review then delves into the potential of cyanobacteria as industrial workhorses, and the current state of genetic and metabolic engineering strategies for these organisms. Recent progress in developing molecular tools for cyanobacteria, including promoters, terminators, and gene regulation systems, is outlined. Finally, a theoretical route from carbon dioxide to indigo is proposed based on the gathered literature. This approach could potentially lead to carbon-negative indigo production, contributing to a circular economy model and demonstrating the broader applicability of cyanobacteria as prokaryotic photoautotrophs in the green production of other chemicals. The challenges and future directions for optimizing this process are mentioned, emphasizing the need for more studies.
| Item Type: | Thesis (Bachelor's Thesis) |
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| Supervisor name: | Fraaije, M.W. |
| Degree programme: | Life Science and Technology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 11 Jul 2024 09:28 |
| Last Modified: | 11 Jul 2024 09:28 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/33229 |
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