The influence of sleep disturbance on psychosis in vulnerable individuals, modulated by the dopaminergic system

Tarziu, Larisa-Maria (2024) The influence of sleep disturbance on psychosis in vulnerable individuals, modulated by the dopaminergic system. Bachelor's Thesis, Biology.

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Abstract

The current review explores the influence of sleep disturbances on the emergence of psychotic episodes through modulation of the dopaminergic neurotransmitter system. While substantial research has examined sleep disturbances as a consequence of psychosis, this review investigates how sleep disturbances may contribute to the development of psychosis, a primary group of symptoms found in schizophrenia. Dopamine antagonists, currently used as antipsychotic treatments, provide insights into the relationship between sleep disturbances and psychosis. On the other hand, dopamine agonists such as amphetamine reveal important insight into the endogenous sensitization theory and supersensitivity theory of psychosis. Alterations in dopamine release of D1/D2 dopamine receptors in the striatum have been found in both disturbed sleep and psychosis. Research into schizophrenia reveals strong correlations between altered sleep architecture and duration in schizophrenic patients and an increased risk of psychosis onset in those experiencing sleep problems. Genes of the phosphodiesterase family have been associated with both psychosis and sleep disturbances through their effects on dopamine expression in the medium spiny projection neurons of the striatum. Moreover, the expression of genes involved in sleep-wake regulation is influenced by dopamine. The reviewed literature indicates a relationship between hyperdopaminergia, sleep disturbances and psychosis.

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Gervais, N.
Degree programme:	Biology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	16 Jul 2024 11:32
Last Modified:	16 Jul 2024 11:32
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/33419

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