Danilov, Alexandra (2024) Adhesion of Anisotropic Micelles in Sticky Microchannels. Bachelor's Thesis, Biomedical Engineering.
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Abstract
Polymeric micelles, formed by the self assembly of block copolymers, play a crucial role in science, particularly in nanomedicine, as drug carriers due to their core-shell structure. Using a very simplified molecular dynamics system, this paper investigates the adhesive behavior of polymeric micelles with various aspect ratios (AR) in sticky microchannels simulating blood vessels. Our aim was to analyze how different micelle shapes, adhesion strengths, and channel sizes affect micelle behavior during the drug delivery process. We generated polymers of five different ARs (1, 2:1, 1.6:1, 1:3, 1:4.75) in channels of two different sizes, assessing their mean squared displacement (MSD) and the resulting slopes. Our findings highlight the influence of micelle shape on adhesion and provide insights for optimizing drug delivery systems. Future work should address the limitations of the current model, such as improving simulation parameters to obtain slopes of realistic non-zero values and explore more complex situations to better reflect physiological conditions, for example incorporating realistic blood flow dynamics and experimenting with additional channel sizes and micelle shapes .
| Item Type: | Thesis (Bachelor's Thesis) |
|---|---|
| Supervisor name: | Giuntoli, A. and Giessen, E. van der |
| Degree programme: | Biomedical Engineering |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 26 Jul 2024 14:14 |
| Last Modified: | 26 Jul 2024 14:14 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/33717 |
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