The Impact of Chronic Psychological Stress on the Gut-Brain Axis: Implications for Immune Function and Gastrointestinal Health

Armenaki, Ekavi (2024) The Impact of Chronic Psychological Stress on the Gut-Brain Axis: Implications for Immune Function and Gastrointestinal Health. Bachelor's Thesis, Biology.

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Abstract

This literature review investigates the impact of Chronic psychological stress on the gut-brain axis (GBA) which further have important implications on immune function and overall gastrointestinal (GI) health. CPS disrupts the GBA by altering key signaling pathways such as the hypothalamic-pituitary-adrenal (HPA) axis, sympathetic-adrenal-medullary (SAM) axis, and enteric nervous system (ENS). Studies show how HPA dysregulation leads to Glucocorticoid dysregulation with CPS causing either a state of hyper or hypo-activation of the axis. SAM is led to release catecholamine for prolonged periods, therefore negatively affecting motility and contributing to a state of dysbiosis. ENS further adds to these adverse effects and is influenced by the dysregulation of the other two components. This all causes dysregulated neurotransmitter and hormone release leading to systemic inflammation, gut barrier dysfunction and dysbiosis. This state of inflammation is linked to the pathophysiology as well as exasperation of GI disorders, such as Inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Therefore, this review will also mention a few of the existing potential therapies in order to minimize the adverse effects of CPS as well as highlight the importance of understanding this dysfunction and the need for further research.

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Eisel, U.L.M.
Degree programme:	Biology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	30 Jul 2024 09:41
Last Modified:	30 Jul 2024 09:41
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/33747

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