Klaauw, Isabel van der (2024) The Influence of Pregnancy-Associated Hormones on Immune Responses and the Contribution of Immuno-Endocrine Crosstalk to Successful Pregnancy. Bachelor's Thesis, Biology.
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Abstract
Pregnancy is a fascinating phenomenon when it comes to tolerance of the fetus by the maternal immune system. A fetus consists partially of foreign material, namely the fathers, making it semiallogeneic. However, instead of attacking, the immune system starts to switch from a pro- to anti-inflammatory environment after early pregnancy. This is achieved together with a variety of hormones, of which estrogens, progesterone, hCG and relaxin are discussed due to their prominent roles in gestation and recurrence in studies. The immunological shift can be divided into two physical locations: the maternal periphery and maternal-fetal interface. Pregnancy-associated hormones can alter a variety of immune cells, including macrophages, T helper cells, regulatory T cells and natural killer cells. Several cytokines such as IL-10, TGF-β and IFN-γ have shown to be affected as well. The present thesis focuses on the key hormonal changes during pregnancy, how these hormones regulate immunological modulation and how immune-endocrine crosstalk contributes to successful pregnancy. Key words: Pregnancy, immune-endocrine crosstalk, fetal tolerance, immunological shift, maternal-fetal interface, maternal periphery, estrogens, progesterone, hCG, relaxin.
| Item Type: | Thesis (Bachelor's Thesis) |
|---|---|
| Supervisor name: | Faas, M.M. |
| Degree programme: | Biology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 06 Aug 2024 13:47 |
| Last Modified: | 06 Aug 2024 13:47 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/33881 |
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