Witziers, Sanne (2024) CRISPR-Cas in the clinic: The current state-of-the-art and what holds its clinical application back. Master's Thesis / Essay, Biomedical Sciences.
|
Text
mBMS2024WitziersS.pdf.pdf Download (514kB) | Preview |
|
![[img]](https://fse.studenttheses.ub.rug.nl/style/images/fileicons/text.png) |
Text
toestemming Witziers.pdf Restricted to Registered users only Download (181kB) |
Abstract
CRISPR-Cas represents a rapidly evolving and highly promising tool for precise genome editing and the modulation of gene expression. There are various CRISPR-Cas systems which operate through a fundamentally similar mechanism but possess unique characteristics. Currently, the CRISPR-Cas technology is extensively implemented in plant and animal science as well as in biomedical research to establish animal models of human diseases. Nevertheless, this technique holds significant potential for offering novel therapeutic interventions for treating and curing a wide range of diseases in the future. This essay examines the current clinical applications of CRISPR-Cas, particularly its potential to treat monogenic blood disorders and specific cancers, and its role in the early detection of pathogens and in combating antibiotic resistance in bacteria. Once challenges such as off-target effects, immunogenicity, and ethical considerations are addressed, CRISPR-Cas holds the potential to be implemented as a revolutionary intervention in modern healthcare.
| Item Type: | Thesis (Master's Thesis / Essay) |
|---|---|
| Supervisor name: | Westers, H. |
| Degree programme: | Biomedical Sciences |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 18 Sep 2024 13:51 |
| Last Modified: | 18 Sep 2024 13:51 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/34239 |
Actions (login required)
 |
View Item |