Understanding the role of non-neutralizing antibodies in immunity against Influenza

Dutta, Roshni Esther (2024) Understanding the role of non-neutralizing antibodies in immunity against Influenza. Bachelor's Thesis, Biology.

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Abstract

Non-neutralizing antibodies (nNAbs) and Neutralizing antibodies (NAbs) are part of the adaptive immune system that play a protective role during infection. Neutralizing antibodies block the pathogens and prevent their spread by attaching to them, non-neutralizing antibodies only attach to the pathogens but don’t directly prevent infection.They work by interacting with immune mechanisms such as Antibody-Mediated Complement dependent cytotoxicity (CDC), antibody-dependent cellular phagocytosis(ADCP), and antibody-dependent cellular cytotoxicity (ADCC). The high rate of mutation in the influenza virus has proved to be a challenge in building a universal vaccine. nNAbs also provide cross-strain immunity by targeting conserved viral areas, such as internal proteins like nucleoproteins (NP) and Matrix-2 (M2) ion channels, which are less prone to mutate. Given this ability to target conserved regions, nNAbs may be essential to the development of future universal vaccination programs.This thesis investigates the role of these nNAbs particularly in influenza, their influence on immune response, potential in future vaccine development, and implications for broader disease protection strategies.

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Huckriede, A.L.W.
Degree programme:	Biology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	16 Oct 2024 07:18
Last Modified:	16 Oct 2024 07:18
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/34319

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