Hendriks, T.G. (2025) High fat diet induced liver and kidney damage in hepatocyte specific CBS knockout mouse model, a ROS mediated theory? Research Project, Pharmacy.
|
Text
mPHAR2025HendriksTG.pdf Download (1MB) | Preview |
|
![[img]](https://fse.studenttheses.ub.rug.nl/style/images/fileicons/text.png) |
Text
Toestemming.pdf Restricted to Registered users only Download (214kB) |
Abstract
Non-Alcoholic fatty liver disease (NAFLD) has become one of the leading causes for liver diseases worldwide. More than 30 % of the population is affected by this disease and the numbers are still rising. This illustrates the necessity of more research into the development and treatment of NAFLD to tackle this global burden. In this study we looked into the development of NAFLD in a hepatocyte specific CBS knockout mouse model. Control wildtype mice were able to withstand a high-fat diet without signs of NAFLD such as elevated ALAT levels, ROS production and kidney damage. The CBS knockout animals however showed liver- and kidney damage and increased ROS production when fed a High-fat diet. ROS correlates with ALAT, kidney damage and is therefore likely the main promotor of this HFD induced NAFLD. Since wildtype animals showed no damage when fed a high-fat diet, a beneficial role of hepatic CBS and H2S is expected in the onset and development of NAFLD. A possible treatment of this disease may be found in the future by further investigation of the role of CBS in NAFLD.
| Item Type: | Thesis (Research Project) |
|---|---|
| Supervisor name: | Deelman, L.E. and Schmidt, M. |
| Degree programme: | Pharmacy |
| Thesis type: | Research Project |
| Language: | English |
| Date Deposited: | 29 Apr 2025 08:59 |
| Last Modified: | 29 Apr 2025 08:59 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/35115 |
Actions (login required)
 |
View Item |