Veldhuis, Michelle (2025) Ozempic and The Immune System: Investigating Immunomodulatory Effects and Potentials of Glucagon-like Peptide-1 Receptor Agonists in Autoimmune Diseases. Master's Thesis / Essay, Biomedical Sciences.
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Abstract
GLP-1 receptor agonists (GLP-1RAs) have traditionally been used for glycemic control in type 2 diabetes, and, more recently, for weight loss in obesity. However, emerging research suggests that their therapeutic potential may extend beyond metabolic diseases. This essay explores the immunomodulatory effects of GLP-1RAs and investigates their potential use in treating autoimmune diseases due to these immunomodulatory effects. Via different downstream signaling pathways, GLP-1RAs could be beneficial as an anti-inflammatory agent in the treatment of diseases such as vasculitis, multiple sclerosis, inflammatory bowel disease, and rheumatoid arthritis. Inflammation plays a central role in the pathophysiology of all these diseases, which could potentially be targeted by GLP-1RAs. Additional beneficial effects of GLP-1RAs in neurodegenerative diseases and certain types of cancer are also shortly discussed. To conclude, GLP-1RAs may represent a promising new manner of treating autoimmune diseases, but large-scale clinical trials must be conducted before applying GLP-1RAs on a large scale in the clinic for autoimmune diseases.
| Item Type: | Thesis (Master's Thesis / Essay) |
|---|---|
| Supervisor name: | Smink, A.M. |
| Degree programme: | Biomedical Sciences |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 05 Jun 2025 06:51 |
| Last Modified: | 05 Jun 2025 06:51 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/35294 |
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