Veen, Nienke van der (2025) Parkinson’s and Pesticides: Exploring the Link Between Glyphosate and Parkinson’s Disease. Master's Thesis / Essay, Behavioural and Cognitive Neurosciences.
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Abstract
Parkinson’s Disease (PD) is a progressive neurodegenerative disorder characterised by misfolded α-synuclein accumulation and dopaminergic neuron loss in the substantia nigra. While aging is the primary risk factor, environmental exposures—especially to pesticides—are increasingly recognised as risk factors as well. It is suspected that glyphosate exposure - a widely used herbicide - can contribute to PD development. Case reports describe individuals developing PD following glyphosate exposure, and some epidemiological studies suggest correlations. However, findings are mixed, and some studies report no association. Animal studies have linked glyphosate to motor and memory symptoms. Proposed mechanisms for how glyphosate might contribute to PD development include disruption of the gut microbiome , potential testosterone reduction, and impaired mitochondrial function leading to oxidative stress. Notably, it's unclear if observed effects stem from pure glyphosate or glyphosate-based herbicides, which include co-formulants that may increase toxicity and are often unknown. While a possible link exists, more research is needed to determine causality and underlying mechanisms.
| Item Type: | Thesis (Master's Thesis / Essay) |
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| Supervisor name: | Vries, E.F.J. de |
| Degree programme: | Behavioural and Cognitive Neurosciences |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 05 Aug 2025 07:20 |
| Last Modified: | 05 Aug 2025 07:20 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/36659 |
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