Tarnovetchi, Yasmina Daniela (2025) lncRNAs and miRNAs as Transcriptomic Biomarkers in the Pathophysiology of Mood Disorders. Bachelor's Thesis, Biology.
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Abstract
Mood disorders like major depressive disorder (MDD) and bipolar disorder (BD) represent a significant global health burden, yet their diagnosis still primarily relies on subjective clinical evaluation, which results in high rates of misdiagnosis and treatment resistance. This highlights the critical need for objective biological markers that can aid in improving current clinical outcomes. This review aims to summarize the current findings on the role of non-coding RNAs (ncRNAs), specifically microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), as key transcriptomic regulators in the pathophysiology of mood disorders, as well as evaluate their potential as clinical biomarkers. ncRNAs are frequently dysregulated in MDD and BD, acting as a crucial link between the genetic predisposition and the clinical manifestation of these disorders. miRNAs and lncRNAs are mainly involved in biological mechanisms, such as synaptic plasticity and excitability, neuroinflammation, HPA axis regulation, and olfactory dysfunction. While the field of transcriptomics has produced strong findings, there are also many limitations that prevent the implementation of ncRNAs as clinical biomarkers. In conclusion, ncRNAs play a key role in the molecular pathways underlying mood disorders, holding high potential as future biomarkers for diagnosis, prognosis, and treatment response prediction in the pathophysiology of mood disorders.
| Item Type: | Thesis (Bachelor's Thesis) |
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| Supervisor name: | Holtman, I.R. and Fortunato Asquini, T. |
| Degree programme: | Biology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 30 Sep 2025 07:04 |
| Last Modified: | 30 Sep 2025 07:04 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/37057 |
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