Nigro, Gerardo (2025) Unravelling Parkinson’s disease: could Mitochondria and α-Synuclein hold the key to a Cure? Master's Thesis / Essay, Biomedical Sciences.
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Abstract
Parkinson’s disease (PD) is a progressive neurodegenerative disease affecting millions of people worldwide, characterized by loss of dopamine neurons. The presence of α-synuclein protein aggregates and mitochondrial dysfunction play a key role in disease progression, creating a vicious cycle that drives neurodegeneration. This essay focuses on current knowledge of mitochondrial and α-synuclein mechanisms in PD, evaluating the most promising therapies. It discusses treatments aimed at restoring mitochondrial health (like gene therapies, mitophagy enhancers, and mitochondrial biogenesis stimulators) and approaches targeting α-synuclein aggregation (like immunotherapies and molecular agents), separately. Then, the great potential of combined therapies that address both mitochondrial dysfunction and α-synuclein, such as iCP-parkin (improved-Cell Permeable Parkin), is highlighted. This holds the promise of modifying the progression of PD, with the hope of giving patients a better life.
| Item Type: | Thesis (Master's Thesis / Essay) |
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| Supervisor name: | Eisel, U.L.M. and Dolga, A.M. |
| Degree programme: | Biomedical Sciences |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 21 Oct 2025 07:16 |
| Last Modified: | 21 Oct 2025 07:16 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/37092 |
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