Bocsan, Andrada (2026) From foetal to neonatal: The role of regulatory T cells in immune development. Master's Thesis / Essay, Biomedical Sciences.
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Abstract
Infectious diseases are associated with 30% of neonatal mortalities, leading to approximately 3 million infant deaths worldwide. Immune dysregulation in utero is theorised to be a key player in the development of sepsis, respiratory disorders, and neurodevelopmental complications in infants. Regulatory T cells, a subpopulation of T cells, are known to influence immunosuppressive responses and maintain tolerance to both maternal and environmental antigens. The FOXP3 transcription factor regulates them to exert their immunosuppressive effects. Several studies have proposed that Treg cell dysregulation and dysfunction in utero can enable invading pathogens to evade immunosuppression, resulting in the presentation of ‘immature immunity’ in neonates, thereby increasing susceptibility to diseases such as bronchopulmonary dysplasia, necrotising enterocolitis, and respiratory syncytial virus. An in-depth analysis of normal immune development, Treg cell biology, and mechanisms and consequences of Treg cell dysregulation is discussed.
| Item Type: | Thesis (Master's Thesis / Essay) |
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| Supervisor name: | Faas, M.M. |
| Degree programme: | Biomedical Sciences |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 21 Apr 2026 11:48 |
| Last Modified: | 21 Apr 2026 11:48 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/37296 |
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