Luiten, Gijs (2026) Diffusion kinetics of optical clearing agents in tissue clearing from millimeter-sized biopsies to centimeter-sized organs. Master's Thesis / Essay, Physics.
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Abstract
Tissue clearing is done to enable detecting signals from fluorescent labels deep within a specimen, permitting three-dimensional imaging of structures within these specimens. Firstly, this study explores the temporal and spatial evolution of transparency during the clearing process, focusing on the diffusion mechanisms of optical clearing agents, such as benzyl alcohol benzyl benzoate. Secondly, the quantitative influence of tissue composition on this diffusion process is investigated, which was previously largely unexplored. Thirdly, optical tissue clearing is applied on a porcine thyroid to investigate the compatibility of hydrophobic optical tissue clearing with (multi)spectral optoacoustic imaging.
| Item Type: | Thesis (Master's Thesis / Essay) |
|---|---|
| Supervisor name: | Zaag, P.J. van der |
| Degree programme: | Physics |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 16 Jul 2026 11:58 |
| Last Modified: | 16 Jul 2026 11:58 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/37426 |
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