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Immunomodulation through indoleamine 2,3-dioxygenase

Kema, M.H.S. (2009) Immunomodulation through indoleamine 2,3-dioxygenase. Bachelor's Thesis, Biology.

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Indoleamine 2,3-dioxygenase (IDO) is an enzyme involved in tryptophan (Trp) catabolism and is principally induced by interferon-gamma. Trp, one of the essential amino acids, is required for adequate T-cell functioning. By depleting local Trp resources IDO facilitates in, among others, induction of T-cell proliferation arrest. Furthermore, IDO is involved in tolerization through antigen-presenting cells and induction of T-cell anergy. Such interdependence allows modulation of the immune response within a specific microenvironment through IDO. This strategy is useful in multiple scenarios: it prevents an adaptive immune reaction from escalating, but also averts rejection of developing fetuses by pregnant women due to foreign MHC and antigens. Conversely, cancer utilizes IDO to permit malignant growth and avoid the host’s immune system. Insights into mechanisms -such as the IDO pathway- allows better understanding of pathophysiology of tumors, which might then provide either new or additional starting points for treatment.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:28
Last Modified: 15 Feb 2018 07:28

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