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Cancer Stem Cells in Solid Tumors:

Clevers, W.J. (2009) Cancer Stem Cells in Solid Tumors:. Bachelor's Thesis, Biology.

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Cancer, the number one disease in the Netherlands, killed over 40.000 people in 2008 in the Netherlands. Years of intense studies on this subject shed new lights on the mechanism and the treatment of the disease. For years scientists believed that every single cell in the human body could mutate in a cancerous cell. Nowadays, this perspective has changed with the arrival of the Cancer Stem Cell (CSC) theory, which states that only tissue stem and progenitor cells can mutate into cancer cells. CSCs are at the base of growth and malignant properties of the tumor. There is still some controversy about the CSC and its existence. In this review the existence of the CSC will be confirmed and the CSC characteristics are linked to the tumor phenotype. CSCs are relatively resistant to anti cancer therapies because of their healthy stem cell origin. This review describes several pathways for drug resistance in CSCs. At the end, three tumors are discussed; glioblastoma multiforme, ovarian- and colon cancer. These tumors originate from CSCs and show therapy resistance, which both will be discussed.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:28
Last Modified: 15 Feb 2018 07:28

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