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Pre-eclampsie De theorieën en feiten van een overmatige ontstekingsreactie tijdens de zwangerschap

Verhaag, E.M. (2009) Pre-eclampsie De theorieën en feiten van een overmatige ontstekingsreactie tijdens de zwangerschap. Bachelor's Thesis, Biology.

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Preeclampsia is one of the most prevailing diseases during pregnancy, occurring in 3% to 5% of the pregnancies. The disease is known for more than 4000 years, however there is no effective treatment available. Preeclampsia is defined by hypertension and proteinuria during pregnancy and is a leading cause of maternal and fetal death. Preeclampsia can be caused by pre-existing conditions such as chronic hypertension, diabetes and obesity, or by impaired placental development. The cause and pathogenesis of preeclampsia are still not know, it is assumed that preeclampsia is caused by a systemic inflammatory response. During preeclampsia immune cells are more activated compared to normal pregnancy. In this inflammatory response monocytes, neutrophils, NK cells and endothelial cells are involved. The cause of the activation of the immune system is still unknown, several placental factors have been proposed as the cause of preeclampsia, however none of these factors is the proven cause. It is likely that a combination of several placental factors cause preeclampsia. The failure to discover the cause of preeclampsia and to develop a therapy points out how complicated this disease is. More research is needed to learn more about the cause and pathogenesis of preeclampsia and eventually to develop a therapy.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:28
Last Modified: 15 Feb 2018 07:28

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