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Pre-existing immunity to novel pandemic influenza A viruses

Bommel P.E. van (2010) Pre-existing immunity to novel pandemic influenza A viruses. Bachelor's Thesis, Biology.

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The recent 2009 influenza A H1N1 pandemic has killed at least 17.000 people and is still ongoing. In addition, the more pathogenic H5N1 avian flu remains cause for concern despite the fact that human cases are rare. Although there are several indications for pre-existing immunity to these novel strains, little is known about underlying mechanisms and the consequences of vaccination to seasonal influenza. Recent studies indicate that pre-existing immunity to 2009 H1N1 and to H5N1 is mediated by B-cell as well as T-cell immunity. Strikingly, neutralizing antibodies to H1N1 are the most abundant in the population >65 years. Furthermore, the development of T-cell immunity to H5N1, and probably also to H1N1, is impeded by vaccination. Together, these findings suggest important considerations are to be made with respect to vaccine design and targeting.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:31
Last Modified: 15 Feb 2018 07:31

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