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The Role of the MRN Complex in Cancer

Zeilstra, F. (2010) The Role of the MRN Complex in Cancer. Bachelor's Thesis, Biology.

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Exogenous or endogenous DNA damaging agents can threaten the genomic integrity of a cell. Therefore, there are cell cycle checkpoints to prevent passing on genomic instability as well as DNA repair mechanisms. Two major double-strand break repair mechanisms exist; non-homologous end joining (NHEJ) and homologous recombination (HR). The MRN complex is involved in both processes and especially plays a pivotal role in HR together with ataxia telangiectasia mutated (ATM). Mutations in the complex or the ATM gene cause severe disorders, sensitivity to radiation and predisposition to several types of cancer because of the failure to repair DSBs. However, the protein complex also appears to be an attractive target for anticancer therapies due to its involvement in both repair machinery.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:31
Last Modified: 15 Feb 2018 07:31

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