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Intracellular non-genomic effects of glucocorticoids in the brain and other tissues

Smink, A.M. (2010) Intracellular non-genomic effects of glucocorticoids in the brain and other tissues. Bachelor's Thesis, Biology.

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Evidence obtained from many different types of experiments indicates that during emotionally arousing experiences the adrenal stress hormone corticosterone play a critical role in memory consolidation. Classically, glucocorticoids (GCs), as corticosterone, act through genomic receptors. Nevertheless, there is increasing evidence that GCs also use several other, non-genomic pathways to induce an effect. Several effects of GCs cannot be regulated by a genomic pathway, for example some physiological and behavioral effects that occur as a result of GCs release appear too fast to be mediated through a genomic action. The non-genomic mechanisms of GCs during memory consolidation are poorly understood. This review is about non-genomic mechanisms of GCs in the brain and other tissues, in order to understand the glucocorticoid mechanisms on cellular level during emotional memory consolidation. In order to obtain insight in possible non-genomic mechanisms of GCs in the brain, non-genomic effects of glucocorticoids on the calcium content in different peripheral cell types will be reviewed. Calcium transport is of vital important for almost all the cells in an organism and in a large number of cells GCs influence this transport mechanism non-genomically. These non-genomic mechanisms observed in peripheral cell types are similar to some mechanisms that are observed in the brain during memory consolidation. These studies indicate that GCs may act also through non-genomic mechanisms in the brain, like in the periphery, to interfere with synaptic transmission and therefore, with memory consolidation.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:31
Last Modified: 15 Feb 2018 07:31

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