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Exotoxic Virulence Factors of Streptococcus pygenes

Elwenspoek, M.M.C. (2010) Exotoxic Virulence Factors of Streptococcus pygenes. Bachelor's Thesis, Biology.

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Streptococcus pyogenes is a human pathogen that has been causing life-threatening diseases throughout history. From the 1980s the incidence of severe invasive infections, such as Necrotising fasciitis and Streptococcal toxic shock syndrome, increased substantially. Streptococcus pyogenes can secrete a wide range of toxins that contribute to its virulence. One of these toxins is the streptococcal pyrogenic exotoxin B (SpeB), which is an important enzymatic toxin. By cleaving host and bacterial molecules SpeB contributes to inflammation and tissue damage. In addition, it facilitates invasion of the bacteria and helps evading the immune system. Beside enzymatic toxins, Streptococcus pyogenes secretes toxins that elicit an immense immune reaction, called superantigens. Via activation of the transcription factor NFκB, transcription is altered in many cell types, which eventually can induce a state of shock. This review will address the pathogenesis of Streptococcus pyogenes. In particular, the role of SpeB and superantigenic toxins will be addressed. Furthermore, herein the leading hypothesis of the sudden rise in invasive infections will be discussed.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:31
Last Modified: 15 Feb 2018 07:31

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