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Potential targets to reverse atrial remodeling induced by atrial fibrillation

Dijkstra, S. (2010) Potential targets to reverse atrial remodeling induced by atrial fibrillation. Bachelor's Thesis, Biology.

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Atrial fibrillation (AF) is one of the most common cardiac arrhythmias and is an important contributor to cardiovascular morbidity and mortality. The self-perpetuating nature of AF is divided into two major pathophysiological mechanisms: electrical and structural remodeling. Cardiomyocyte stress results in early remodeling, such as contractile dysfunction and changes in action potential duration and later on in down-regulation of L-type calcium channels and structural remodeling, most importantly myolysis, which contribute to contractile dysfunction. The reversal of electrical remodeling is a very fast process, during 3-4 days, in contrast to the reversal of structural remodeling which takes at least several months. Since AF-recurrences also occur one week after cardioversion, the persisting high susceptibility must be a result of the process of structural remodeling. To manage AF, therapies should therefore focus on the reversibility of structural remodeling. Treatment possibilities nowadays focus on rhythm and rate control, which control only electrical properties. To manage AF by improving the arrhythmogenic substrate, future research should focus on drugs that reverse structural remodeling. These potential drugs are angiotensin II type-1 receptor blockers, statins, multi-channel blockers and miRNAs. The action mechanism of these drugs have to be investigated because of their reversible actions on structural remodeling in myocytes.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:44
Last Modified: 15 Feb 2018 07:44

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