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Multi-functionality of aminoacyl-tRNA synthetases

Schavemaker, P.E. (2010) Multi-functionality of aminoacyl-tRNA synthetases. Bachelor's Thesis, Biology.

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The role of aminoacyl-tRNA synthetases (aaRSs) in translation is known by everyone in the field of molecular biology. What people often do not realize, however, is that aaRSs are involved in a lot of processes apart from translation. AaRSs are involved in processes like transcriptional and translational regulation, antibiotic resistance, synthesis of unnatural amino acids, cell signaling and many more. This multi-functionality of aaRSs occurs in all three domains of life. Here I will discuss the extend of this multifunctionality in bacteria. I will compare the complexity of bacterial aaRS multi-functionality to that of eukaryotes. Finally I will describe new insights in bacterial complexity obtained from interactome studies. This literature study shows that bacterial aaRS multi-functionality is a lot less complex than that of eukaryotes. The most important point, however, is that the complexity of the functions of bacterial aaRSs may be drastically underestimated.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:44
Last Modified: 15 Feb 2018 07:44

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