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Peptide self-replication driven by self-assembly

Eising, S. (2010) Peptide self-replication driven by self-assembly. Bachelor's Thesis, Chemistry.

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Self-replication of molecules is probably an essential process in the origin of life. Selfreplicating molecules can be observed with dynamic combinatorial chemistry and already a small numbers of self-replicators are found with this technique. Peptide-derived self-replicating behaviour is achieved with small dynamic combinatorial libraries of a self-binding building block. Fibres are formed from the macrocycles of the building block, because of the stabilisation by the A-sheets between the peptides of the building blocks. To understand better which factors provide the self-assembly and selfreplication of molecules, varying the building block structure is a useful tool. Here the first steps of the synthesis of 2-(2,7-dimercapto-9Hfluoren-9-yl)acetic acid out of fluorene is described.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Chemistry
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:45
Last Modified: 15 Feb 2018 07:45

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