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Which stem cell for cardiomyocyte generation?

Mohaupt S. (2010) Which stem cell for cardiomyocyte generation? Bachelor's Thesis, Biology.

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Heart failure coincides various abnormal physiological and functional conditions of the heart. The loss of cardiomyocytes and the resulting change in heart structure are the main causes of heart failure. This review focuses on the replacement of the lost cardiomyocytes by stem cell therapy. There are 4 types of stem cells available: Adult stem cells, embryonic stem cells, cardiac stem cells and induced pluripotent stem cells. Each stem cell has specific advantages and disadvantages that are relevant for their use in stem cell therapy. Induced pluripotent and embryonic stem cells have the risk of forming teratomas, which is unacceptable. Cardiac stem cells are mostly lost in patients suffering heart failure. Therefore the stem cells with the most potential in stem cell therapy are adult stem cells. However, the replacement of the cardiomyocytes is only one part of the solution. The other part consists of reversing the structural changes that are typical in the failing heart.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:45
Last Modified: 15 Feb 2018 07:45

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