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The current stage of drug development based upon the function and dysfunction of TRP channels

Jong, E. de (2010) The current stage of drug development based upon the function and dysfunction of TRP channels. Bachelor's Thesis, Biology.

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Precisely controlled movements of ions into and out of cells and organelles are essential for life. TRP channels are a large class of channels that are united by a common primary structure and permeability to monovalent cations and calcium ions. They open and close to regulate cation entry into the cell. TRP channels play a crucial role in all the senses that allow humans to perceive the outside world. Because of the involvement of TRP channels in many physiological processes, it might not be surprising that some of the subfamilies are involved in human diseases. In this review we want to show the current stage in drug development targeting TRP channels in pain, cancer and polycystic kidney disease (PKD). In the management of pain, TRPV1 has become a viable drug target for clinical use. Several synthetic antagonists of the TRPV1 channel are progressed into clinical development focused primarily for use in the treatment of pain. In cancer, TRP channels may serve as prognostic/diagnostic markers or as therapeutic target for activation of the apoptotic pathway or delivering a toxic payload. The disturbance of the interaction between TRPP1 and TRPP2 in PKD has led to the discovery of novel potential therapeutic targets, although the majority of the drugs successfully tested so far were not specifically designed to treat PKD. Last decade, the scientific world opened the gate of TRP channels, but many years of research is required to pass through TRP channels.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:45
Last Modified: 15 Feb 2018 07:45

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