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Schizophrenia; a neurotransmitter model

Aa, J.H.M. van der (2011) Schizophrenia; a neurotransmitter model. Bachelor's Thesis, Biology.

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Schizophrenia is a mental disorder which we are currently beginning to understand. Performed research has allowed a neurotransmitter model to be formulated which could explain the positive symptoms of schizophrenia. In this thesis a literature study has been performed to investigate the role of neurotransmitters in the origin of positive symptoms in schizophrenia. Hypofrontality is the cause of both a hypoactive dopaminergic mesocortical projection and a hyperactive dopaminergic mesolimbic projection. The hypoactive mesocortical projection seems to be the cause of the negative symptoms of schizophrenia, while the hyperactive mesolimbic projection appears to be the cause of the positive symptoms of schizophrenia. The hyperactive mesolimbic projection reduces latent inhibition. This could cause a sensory overload of the cortex which could produce positive symptoms. These dopamine projections seem to be regulated by a system involving both glutamate and GABA. However, this model does not explain everything about schizophrenia. Therefore more research should be performed to fully understand schizophrenia.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:45
Last Modified: 15 Feb 2018 07:45

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