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Microglia: the physiology and its role in the aging brain

Smit, T.T.A. (2011) Microglia: the physiology and its role in the aging brain. Bachelor's Thesis, Biology.

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Microglia are resident immune cells of the CNS and have a distinct phenotype in the healthy brain, induced by ‘off’ signals expressed by neurons and astrocytes. In reaction to disturbance in the CNS, microglia change their morphology and phenotype towards a beneficial or detrimental state, thereby regulating the disease pathology. Microglial activation is very diverse and dynamic, regulated by ‘on’ signals, also released by neurons and astrocytes. Normal aging of the brain is accompanied with increased microglial activation and enlarged microglial subtypes, increasing the risk of neurogenerative diseases. A better comprehension of microglial behavior will be necessary in understanding the pathogenesis of ischemia and neurogenerative diseases, in order to develop effective therapies.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:45
Last Modified: 15 Feb 2018 07:45

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